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Age, sex and vitamin status affect plasma level of homocysteine, but hyperhomocysteinaemia is possibly not an important risk factor for venous thrombophilia in Taiwanese Chinese
Author(s) -
Lin JenShiou,
Shen MingChing,
Cheng WernCherng,
Tsay Woei,
Wang YingChi,
Lin BinBin,
Hung MeiHua
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03384.x
Subject(s) - thrombophilia , medicine , odds ratio , homocysteine , venous thrombosis , risk factor , thrombosis , confidence interval , gastroenterology , hyperhomocysteinemia
Summary. The biological effects of age, sex and vitamin status on plasma total homocysteine (tHcy), and association of hyperhomocysteinaemia with venous thromboembolism in Taiwanese Chinese individuals, were investigated. Eighty patients (16–85 years) with venous thrombophilia and 123 healthy subjects (15–85 years) without history of vascular thrombosis were studied for plasma levels of tHcy, folate and vitamin B 12 . A multivariate analysis in healthy subjects revealed that plasma tHcy levels tended to increase with age ( P < 0·001) and with decreasing plasma levels of folate ( P =0·001) or vitamin B 12 ( P < 0·029); men tended to have higher plasma tHcy levels than women ( P =0·006). Thrombotic risk assessment in a case–control study demonstrated that neither plasma level of tHcy [odds ratio (OR), 1·07; 95% confidence interval (CI), 0·96–1·18; P =0·210] nor hyperhomocysteinaemia (OR, 1·65; 95% CI, 0·50–5·49; P =0·415) was significantly associated with venous thrombophilia. The relationship between hyperhomocysteinaemia and recurrence of episode remained insignificant ( P =0·560). We conclude that age, sex and vitamin status affect plasma tHcy but hyperhomocysteinaemia is possibly not an important risk factor for venous thrombophilia in Taiwanese Chinese.