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Non‐myeloablative bone marrow transplantation in an adult with Wiskott–Aldrich syndrome
Author(s) -
Longhurst Hilary J.,
Taussig David,
Haque Tanzina,
Court Denise Syndercombe,
Cavenagh Jamie,
Edgar J. David,
Helbert Matthew R.
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03269.x
Subject(s) - wiskott–aldrich syndrome , medicine , bone marrow transplantation , transplantation , vasculitis , bone marrow transplant , bone marrow , immunology , surgery , disease , biochemistry , chemistry , gene
Summary. Early bone marrow transplant is now standard treatment for infants with severe immunodeficiencies such as Wiskott–Aldrich Syndrome (WAS), but results in older children and adults are poor. Non‐myeloablative transplant has shown promise in the treatment of older children, who are likely to have active infections and organ damage. We describe a non‐myeloablative transplant of a 26‐year‐old man with WAS, undertaken because of severe infections and vasculitis. Partial engraftment and immunorestoration were achieved. The patient is well 1 year post transplantation.