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Interleukin 8 and venous thrombosis: evidence
for a role of inflammation in thrombosis
Author(s) -
Van Aken Benien E.,
Reitsma Pieter H.,
Rosendaal Frits R.
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03245.x
Subject(s) - medicine , venous thrombosis , thrombosis , thrombophilia , odds ratio , risk factor , gastroenterology , population , coagulation , case control study , surgery , environmental health
Summary. Elevated plasma levels of interleukin 8 (IL‐8) were previously shown to be associated with recurrent venous thrombosis. To assess the risk of venous thrombosis, IL‐8 plasma concentrations were measured in patients and control subjects of the Leiden Thrombophilia Study (LETS). This population based case–control study included 474 patients with a first deep‐vein thrombosis and 474 age‐ and sex‐matched controls. The risk of venous thrombosis for subjects with elevated IL‐8 levels (above 90th percentile of controls) compared with subjects with IL‐8 levels below the 90th percentile was increased 1·8‐fold (95%CI 1·2–2·8). Adjusted for age and sex, the odds ratio was 1·9 (95%CI 1·3–2·8). IL‐8 concentrations were weakly correlated with age, male sex, and concentrations of C‐reactive protein, factor VIII coagulation activity and homocysteine, but adjustment for these factors did not substantially affect the association between IL‐8 and venous thrombosis. Our results suggest that IL‐8 is a risk factor for venous thrombosis.