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Burkitt's acute lymphoblastic leukaemia transformatation after myelodysplastic syndrome
Author(s) -
Ikeda Takashi,
Sato Ken,
Yamashita Takuya,
Kanai Yoshiaki,
Kuwada Naruo,
Matsumura Takuya,
Nakamura Yukitsugu,
Kimura Fumihiko,
Motoyoshi Kazuo
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.03098.x
Subject(s) - cd19 , myelodysplastic syndromes , cd38 , antigen , acute lymphocytic leukemia , medicine , cancer research , antibody , cytogenetics , karyotype , immunology , gene , biology , leukemia , bone marrow , lymphoblastic leukemia , cd34 , chromosome , genetics , stem cell
We describe a patient with myelodysplastic syndrome (MDS) that transformed to Burkitt's acute lymphoblastic leukaemia (ALL). The leukaemic blasts were negative for peroxidase staining, and expressed CD10, CD19, CD22, CD38, human leucocyte antigen (HLA)‐DR and surface immunoglobulin (sIg) M, but neither sIgD nor sIgG were expressed. Chromosomal study during the ALL phase showed t(8;22)(q24;q11) in addition to the karyotypes determined during the MDS phase. Furthermore, overexpression of c ‐myc mRNA was confirmed in ALL blasts. These findings indicate that MDS transformed to Burkitt's ALL through multiple cytogenetic evolutions, the final event of which seems to be overexpression of the c ‐myc gene.