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High expression of platelet‐derived growth factor and transforming growth factor‐β1 in blast cells from patients with Down Syndrome suffering from transient myeloproliferative disorder and organ fibrosis
Author(s) -
Hattori Hiroyoshi,
Matsuzaki Akinobu,
Suminoe Aiko,
Ihara Kenji,
Nakayama Hideki,
Hara Toshiro
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.03093.x
Subject(s) - platelet derived growth factor , platelet derived growth factor receptor , growth factor , transforming growth factor , fibrosis , medicine , cancer research , pathology , immunology , receptor
To determine whether platelet‐derived growth factor (PDGF) and transforming growth factor‐β1 (TGF‐β1) are involved in organ fibrosis in patients with transient myeloproliferative disorder (TMD) in Down syndrome, the expression of PDGF and TGF‐β1 mRNA in blast cells of TMD was investigated using real‐time quantitative reverse transcription polymerase chain reaction. Blasts and liver tissue from TMD patients with hepatic fibrosis showed a significantly elevated expression of PDGF gene. The expression of TGF‐β1 gene was higher in TMD and acute megakaryoblastic leukaemia than in the control group. These results suggest that PDGF in combination with TGF‐β1 plays a role in organ fibrosis of TMD.