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Blastic mantle cell lymphoma associated with Burkitt‐type translocation and hypodiploidy
Author(s) -
Vaishampayan Ulka N.,
Mohamed Anwar N.,
Dugan Michael C.,
Bloom Robert E.,
Palutke Margarita
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.03056.x
Subject(s) - mantle cell lymphoma , fluorescence in situ hybridization , chromosomal translocation , blastoid , fusion gene , oncogene , lymphoma , biology , cancer research , cyclin d1 , virology , gene , immunology , cell cycle , genetics , chromosome
Two elderly men with stage IV mantle cell lymphoma (MCL) rapidly developed a leukaemic phase with unusually high blast counts that proved fatal. One lymph node biopsy showed diffuse MCL, the other blastic morphology. In addition to t(11;14), there were t(8;14) and t(1;19) in case 1 and dup(8)(q24q13) in case 2. Fluorescence in situ hybridization revealed genomic fusion of IgH/MYC genes in case 1 and an extra copy of C‐MYC gene in case 2. The genomic alteration of C‐MYC oncogene is probably implicated in the blastic transformation and aggressive behaviour of the disease.