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Unrelated cord blood transplantation for adult patients with myelodysplastic syndrome‐related secondary acute myeloid leukaemia
Author(s) -
Ooi Jun,
Iseki Tohru,
Nagayama Hitomi,
Tomonari Akira,
Ito Kiyoshi,
Shirafuji Naoki,
Tojo Arinobu,
Tani Kenzaburo,
Asano Shigetaka
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.03049.x
Subject(s) - medicine , cyclophosphamide , transplantation , myelodysplastic syndromes , cord blood , total body irradiation , myeloid , myeloid leukaemia , granulocyte colony stimulating factor , immunology , bone marrow , myeloid leukemia , gastroenterology , chemotherapy
Seven adult patients with myelodysplastic syndrome (MDS)‐related secondary acute myeloid leukaemia (AML) were treated with total body irradiation (TBI), cytosine arabinoside (Ara‐C) and cyclophosphamide (CY), followed by unrelated human leucocyte antigen (HLA)‐mismatched cord blood transplantation (CBT). Granulocyte colony‐stimulating factor (G‐CSF) was infused continuously from 12 h before until the end of Ara‐C therapy to enhance the antileukaemia effect of Ara‐C. Five patients are alive and free of disease at 7–31 months after transplantation. These preliminary results suggest that adult MDS‐related secondary AML patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT.