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Disparity for the minor histocompatibility antigen HA‐1 is associated with an increased risk of acute graft‐versus‐host disease (GvHD) but it does not affect chronic GvHD incidence, disease‐free survival or overall survival after allogeneic human leucocyte antigen‐identical sibling donor transplantation
Author(s) -
Gallardo David,
Aróstegui Juan Ignacio,
Balas Antonio,
Torres Antonio,
Caballero Dolores,
Carreras Enric,
Brunet Salut,
Jiménez Antonio,
Mataix Rodolfo,
Serrano David,
Vallejo Carlos,
Sanz Guillermo,
Solano Carlos,
RodríguezLuaces Marta,
Marín Julián,
Baro Julio,
Sanz César,
Román Jose,
González Marcos,
Martorell Jaume,
Sierra Jorge,
Martín Carmen,
De La Cámara Rafael,
Grañena Albert
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.03013.x
Subject(s) - medicine , histocompatibility , graft versus host disease , minor histocompatibility antigen , immunology , human leukocyte antigen , transplantation , incidence (geometry) , disease , logistic regression , antigen , histocompatibility testing , gastroenterology , major histocompatibility complex , physics , optics
Disparity for the minor histocompatibility antigen HA‐1 between patient and donor has been associated with an increased risk of acute graft‐versus‐host disease (GvHD) after allogeneic human leucocyte antigen (HLA)‐identical sibling donor stem cell transplantation (SCT). However, no data concerning the impact of such disparity on chronic GvHD, relapse or overall survival are available. A retrospective multicentre study was performed on 215 HLA‐A2‐positive patients who received an HLA‐identical sibling SCT, in order to determine the differences in acute and chronic GvHD incidence on the basis of the presence or absence of the HA‐1 antigen mismatch. Disease‐free survival and overall survival were also analysed. We detected 34 patient–donor pairs mismatched for HA‐1 antigen (15·8%). Grades II–IV acute GvHD occurred in 51·6% of the HA‐1‐mismatched pairs compared with 37·1% of the non‐mismatched. The multivariate logistic regression model showed statistical significance ( P : 0·035, OR: 2·96, 95% CI: 1·07–8·14). No differences were observed between the two groups for grades III–IV acute GvHD, chronic GvHD, disease‐free survival or overall survival. These results confirmed the association between HA‐1 mismatch and risk of mild acute GvHD, but HA‐1 mismatch was not associated with an increased incidence of chronic GvHD and did not affect relapse or overall survival.