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Philadelphia (Ph) chromosome‐positive chronic myeloid leukaemia relapsing as Ph‐negative leukaemia after allogeneic bone marrow transplantation
Author(s) -
Au W. Y.,
Lie A. K. W.,
Ma S. K.,
Wan T. S. K.,
Liang R.,
Leung Y. H.,
Kwong Y. L.
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02960.x
Subject(s) - philadelphia chromosome , medicine , cytogenetics , bone marrow , fluorescence in situ hybridization , transplantation , immunology , stem cell , chemotherapy , myeloid , pathology , cancer research , chromosome , chromosomal translocation , biology , genetics , biochemistry , gene
Two patients with Philadelphia chromosome‐positive (Ph + ) chronic myeloid leukaemia (CML) relapsed 1·5 and 5 years after allogeneic bone marrow transplantation (BMT). Although the leukaemias were of recipient origin, t(9;22) could no longer be detected using conventional cytogenetics/fluorescence in situ hybridization or molecularly. Both patients responded to immunotherapy with donor lymphocytes/peripheral blood stem cells, although one patient ultimately relapsed again. These patients were similar to the occurrence of Ph − leukaemias previously described in Ph + CML after treatment with interferon or autologous BMT, and might be relevant in the pathogenesis and monitoring of treatment after BMT in CML.