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Reduced serum ceruloplasmin levels in hereditary haemochromatosis
Author(s) -
Cairo Gaetano,
Conte Dario,
Bianchi Laura,
Fraquelli Mirella,
Recalcati Stefania
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02917.x
Subject(s) - ceruloplasmin , phlebotomy , medicine , hereditary hemochromatosis , hemochromatosis , allele , endocrinology , albumin , serum iron , gastroenterology , chemistry , gene , anemia , biochemistry
As ceruloplasmin (Cp) seems to be involved in iron mobilization, serum Cp levels were measured in 35 patients with hereditary haemochromatosis (HH), 12 with acquired iron overload (AIO) and 36 healthy subjects. Cp was lower in HH patients than in controls ( P < 0·001); no difference was found between untreated HH patients and those on a phlebotomy programme ( P = 0·07) and between the HH patients carrying the normal and the mutated alleles of the HFE gene ( P = 0·8). Cp levels in AIO subjects were significantly higher than in HH patients ( P < 0·004) and similar to those of controls ( P = 0·2). No differences in albumin, α1 acid glycoprotein and copper serum levels were observed in the three groups.