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Clearance of maternal leukaemic cells in a neonate
Author(s) -
Van Der Velden V. H. J.,
Willemse M. J.,
Mulder M. F.,
Szczepański T.,
Langerak A. W.,
Wijkhuijs J. M.,
Van Dongen J. J. M.
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02914.x
Subject(s) - cord blood , polymerase chain reaction , minimal residual disease , medicine , umbilical cord , immunology , peripheral blood , gene , fusion gene , gene rearrangement , disease , leukemia , pathology , biology , genetics
A 36‐week pregnant woman was diagnosed with acute lymphoblastic leukaemia. Delivery was initiated prematurely, and a healthy child was born. Cord blood and peripheral blood samples from the neonate (obtained at 6 weeks, 3 months and 6 months) were analysed for the presence of minimal residual disease by polymerase chain reaction analysis of a leukaemia‐specific IGH gene rearrangement and the E2A–PBX1 fusion gene transcript. In the cord blood sample, a tumour load of ≈ 4 × 10 −4 was found, whereas all later blood samples were negative. Our data indicate that the maternal leukaemic cells did not engraft in the neonate.