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HLA‐A3 increases and HLA‐DR1 decreases the risk of acute graft‐versus‐host disease after HLA‐matched sibling bone marrow transplantation for chronic myelogenous leukaemia
Author(s) -
Clark Richard E.,
Hermans Jo,
Madrigal Alejandro,
Nachbaur David,
Kropshofer Gabriele,
Gratwohl Alois,
Apperley Jane,
Niederwieser Dietger
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02897.x
Subject(s) - human leukocyte antigen , immunology , medicine , bone marrow , transplantation , graft versus host disease , histocompatibility , allele , bone marrow transplantation , disease , antigen , biology , genetics , gene
Frequencies of human leucocyte antigens (HLA)‐A, ‐B and ‐DR were determined in 751 patients with chronic myelogenous leukaemia (CML) reported to the European Group for Blood and Marrow Transplantation after bone marrow transplantation from HLA‐identical family donors and related to the occurrence of graft‐versus‐host disease (GVHD). HLA‐A3 and DR1 were significantly associated with acute GVHD, the first with a higher risk (44% in HLA‐A3 + versus 34% in HLA‐A3 − patients) and the latter with a lower risk (28% in HLA‐DR1 + versus 38% in HLA‐DR1 − patients) for developing acute GVHD grade II–IV. Both factors were independent of known variables for GVHD as shown in a multivariate analysis. The results show that MHC alleles independently influence the incidence of GVHD in bone marrow transplantation from an HLA‐identical donor for first chronic‐phase CML. Possible mechanisms might include an HLA antigen‐specific allele‐associated effect, and/or non‐specific allele‐associated immune hypo‐ or hyper‐responsiveness.