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The role of thrombopoietin in post‐operative thrombocytosis
Author(s) -
Folman Claudia C.,
Ooms Marike,
Kuenen B Bart,
De Jong Shreyas M.,
Vet Raymond J. W. M.,
De Haas Masja,
Von Dem Borne Albert E. G. Kr
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02888.x
Subject(s) - thrombopoietin , thrombocytosis , platelet , medicine , endocrinology , interleukin 11 , cytokine , interleukin , immunology , biology , haematopoiesis , genetics , stem cell
Thrombopoietin (Tpo), the main regulator of thrombocytopoiesis, is a probable candidate to play a role in the increase in platelet counts that is frequently seen after surgery. In the current study, serial blood samples of patients that underwent major surgery were analysed with respect to Tpo kinetics, platelet turnover and inflammatory cytokines. Platelet Tpo content and plasma Tpo levels rose before platelet counts increased, suggesting that Tpo was indeed responsible for the elevation in platelet counts. In addition, an increase in interleukin 6 (IL‐6) levels, but not in IL‐11 and tumour necrosis factor alpha levels, was seen before the rise in Tpo concentration. In vitro , IL‐6 was shown to enhance Tpo production by the HepG2 liver cell line. Thus, increased Tpo levels after surgery, possibly resulting from enhanced Tpo production under the influence of IL‐6 or other inflammatory cytokines, are involved in an enhanced thrombocytopoiesis.