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True histiocytic lymphoma following B‐acute lymphoblastic leukaemia: case report with evidence for a common clonal origin in both neoplasms
Author(s) -
Bouabdallah Réda,
Abéna Pascale,
Chetaille Bruno,
AurranSchleinitz Thérèse,
Sainty Danielle,
Dubus Pierre,
Arnoulet Christine,
Coso Diane,
Xerri Luc,
Gastaut JeanAlbert
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02841.x
Subject(s) - medicine , lymphoma , lymphoblastic lymphoma , histiocyte , acute lymphocytic leukemia , somatic evolution in cancer , lymphoblastic leukemia , hematology , pathology , immunology , leukemia , cancer , immune system , t cell
True histiocytic lymphoma (THL) is a very rare type of non‐Hodgkin's lymphoma (NHL) in which neoplastic cells exhibit markers of histiocytic differentiation. Some cases of THL have been reported in patients with previous acute lymphoblastic leukaemia (ALL), especially in children and young adults, in whom the acute leukaemia was of T‐cell origin. The relationship between the initial lymphoid tumour and the secondary THL remains unclear, as a common monoclonal origin shared by both neoplasms has never been definitively demonstrated. We report a patient with B‐ALL who developed a nodal and extranodal tumour with histological and immunohistochemical features of THL 4 years after the initial diagnosis. Genotypic study showed that both neoplasms contained the same immunoglobulin heavy gene rearrangement, which has not been reported previously.