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Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells
Author(s) -
Dvorakova Dana,
Krejci Pavel,
Mayer Jiri,
Fajkus Jiri,
Hampl Ales,
Dvorak Petr
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02829.x
Subject(s) - haematopoiesis , stem cell , myeloid , medicine , immunology , chronic myeloid leukaemia , transplantation , fibroblast growth factor receptor 1 , cancer research , fibroblast growth factor receptor 3 , receptor , fibroblast growth factor , biology , microbiology and biotechnology
Fibroblast growth factor receptors (FGFR1–4) are implicated in various cellular events, including cell growth and transformation. Here, we showed that patients suffering from chronic myeloid leukaemia (CML) express high levels of FGFR3 mRNA in white blood cells (WBCs). After stem cell transplantation and reconstitution of haematopoiesis, the expression of FGFR3 decreased and was maintained at low levels that are typical of healthy individuals. However, FGFR3 expression became upregulated again in those patients that had accelerated BCR / ABL rearrangement and underwent relapse of leukaemia. Our findings suggest that, in CML, the changing levels of FGFR3 transcripts in WBCs may have prognostic significance.