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Non‐transferrin‐bound iron during allogeneic stem cell transplantation
Author(s) -
Sahlstedt Leila,
Ebeling Freja,
Von Bonsdorff Leni,
Parkkinen Jaakko,
Ruutu Tapani
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02820.x
Subject(s) - transferrin saturation , transplantation , transferrin , medicine , stem cell , immunology , chemistry , iron deficiency , biology , microbiology and biotechnology , anemia
Hydroxyl radical formation catalysed by non‐transferrin‐bound iron (NTBI) might contribute to transplantation‐related complications. The occurrence of NTBI in 10 adult allogeneic stem cell transplantation (SCT) patients was followed for 20 d. The transferrin saturation reached 99% on d −4 and remained > 80% thereafter. NTBI, measured as bleomycin‐detectable iron, was detected for 6–18 d in all patients with a peak on d −4. High transferrin saturation levels were associated with the appearance of NTBI with a threshold at 80% saturation. Prevention of the potential deleterious effects of NTBI might reduce transplantation‐related morbidity.