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Cytogenetic findings and their clinical relevance in myelofibrosis with myeloid metaplasia
Author(s) -
Tefferi Ayalew,
Mesa Ruben A.,
Schroeder Georgene,
Hanson Curtis A.,
Li ChinYang,
Dewald Gordon W.
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02796.x
Subject(s) - myelofibrosis , metaplasia , clinical significance , myeloid , medicine , pathology , immunology , bone marrow
The prognostic significance of bone marrow cytogenetic lesions in myelofibrosis with myeloid metaplasia (MMM) was investigated in a retrospective series of 165 patients. An abnormal karyotype was demonstrated in 57% of patients. At diagnosis ( n = 92), 48% of the patients had detectable cytogenetic abnormalities, and clonal evolution was frequently demonstrated in sequential studies. More than 90% of the anomalies were represented by 20q–, 13q–, +8, +9, 12p–, and abnormalities of chromosomes 1 and 7. Of these, 20q–, 13q– and +8 were the most frequent sole abnormalities, each occurring in 15–25% of the abnormal cases. Trisomy 9 and abnormalities of chromosomes 1 and 7 were equally prevalent but were usually associated with additional cytogenetic lesions. Chromosome 5 abnormalities were infrequent but were over‐represented in the group of patients exposed to genotoxic therapy. In a multivariate analysis that incorporated other clinical and laboratory variables, the presence of an abnormal karyotype did not carry an adverse prognosis. Instead, +8, 12p–, advanced age and anaemia were independent prognostic determinants of inferior survival. In particular, survival was not adversely affected by the presence of either 20q– or 13q–.