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Variant Philadelphia translocations in chronic myeloid leukaemia can mimic typical blast crisis chromosome abnormalities or classic t(9;22): a report of two cases
Author(s) -
Reid Alistair,
Gribble Susan M.,
Huntly Brian J. P.,
Andrews Kathryn M.,
Campbell Lynda,
Grace Colin D.,
Wood Marion E.,
Green Anthony R.,
Nacheva Ellie P.
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02778.x
Subject(s) - chromosomal translocation , karyotype , chronic myeloid leukaemia , biology , cytogenetics , fluorescence in situ hybridization , philadelphia chromosome , chromosome , blast crisis , genetics , cancer research , leukemia , gene
A range of fluorescent in situ hybridization techniques have been used to reveal hidden variant Philadelphia translocations in two cases of Ph‐positive chronic‐phase chronic myeloid leukaemia. In one patient, a highly complex variant Ph translocation affecting four chromosomes had resulted in the formation of structures with the appearance of i(17q) and +8. Misinterpretation of these karyotypes has direct clinical relevance. Our findings illustrate that even established cytogenetic abnormalities may contain cryptic abnormalities beyond the resolution of conventional cytogenetic methods.