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Antibodies to factor XII and recurrent fetal loss in patients with the anti‐phospholipid syndrome
Author(s) -
Jones D. W.,
Mackie I. J.,
Gallimore M. J.,
Winter M.
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02776.x
Subject(s) - lupus anticoagulant , medicine , odds ratio , antibody , antiphospholipid syndrome , risk factor , fetus , cardiolipin , systemic lupus erythematosus , immunology , gastroenterology , phospholipid , endocrinology , pregnancy , biology , disease , membrane , genetics
Forty female patients with either primary anti‐phospholipid syndrome ( n = 26) or systemic lupus erythematosus (anti‐phospholipid syndrome positive) ( n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2‐glycoprotein I and factor XII. Twenty‐one patients had a history of recurrent fetal loss (> 2, mean = 2·6). Lupus anticoagulant positivity showed a weak association with recurrent fetal loss (odds ratio = 1·1). While there was no association between the presence of antibodies to cardiolipin or beta 2‐glycoprotein I with recurrent fetal loss, antibodies to factor XII showed a strong and statistically significant association (odds ratio = 5·4, P = 0·025).