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The risk of pregnancy‐related venous thromboembolism in women who are homozygous for factor V Leiden
Author(s) -
Middeldorp Saskia,
Libourel Eduard J.,
Hamulyák Karly,
Van Der Meer Jan,
Büller Harry R.
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02766.x
Subject(s) - medicine , pregnancy , asymptomatic , factor v leiden , venous thromboembolism , obstetrics , risk factor , relative risk , factor v , gynecology , post partum , venous thrombosis , thrombosis , confidence interval , genetics , biology
The risk of venous thromboembolism (VTE) is increased in pregnancy and during the post‐partum period. The absolute risk for pregnancy‐related VTE in heterozygous women with the factor V Leiden mutation is approximately 2%, but studies on this risk for homozygous women show conflicting results. In a retrospective family study, we found that the risk of pregnancy‐related VTE in women with a symptomatic first‐degree relative was 17% per pregnancy (95%CI 4·7–37·4). Anticoagulant prophylaxis during the post‐partum period appears to be indicated in asymptomatic homozygous women from symptomatic kindred, whereas this could be decided on an individual basis during pregnancy.