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Graft‐versus‐host disease and survival after ABO‐incompatible allogeneic bone marrow transplantation: a single‐centre experience
Author(s) -
Stussi Georg,
Seebach Lutz,
Muntwyler Jörg,
Schanz Urs,
Gmür Jürg,
Seebach Jörg D.
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02734.x
Subject(s) - abo blood group system , medicine , univariate analysis , transplantation , graft versus host disease , confounding , logistic regression , incidence (geometry) , disease , surgery , immunology , multivariate analysis , physics , optics
The effect of ABO‐incompatibility on graft versus host disease (GVHD) and survival was evaluated in 173 consecutive patients receiving allogeneic bone marrow transplantation (BMT). Thirty‐four percent of the patients developed GVHD and univariate analysis suggested a higher incidence of GVHD in minor ABO‐incompatibility than in ABO‐identity (14/30, 47% versus 37/112, 33%; P = 0·02). However, using logistic regression adjusted for potential confounders, the GVHD risk did not differ significantly. During a mean follow‐up time of 59 months, the mortality was 37% and survival was significantly dependent on ABO‐compatibility ( P = 0·004). In particular, patients with bidirectional ABO‐incompatibility had an excess mortality rate (RR, 7·6; 95% CI, 2·5–23·2; P = 0·0004). Taken together, these results suggest that ABO‐incompatibility may represent a risk factor in allogeneic BMT.