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Erythropoietin synthesis by tumour tissues in a patient with uterine myoma and erythrocytosis
Author(s) -
Suzuki Mitsuaki,
Takamizawa Satoru,
Nomaguchi Koji,
Suzu Shinya,
Yamada Muneo,
Igarashi Takashi,
Sato Ikuo
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02682.x
Subject(s) - leiomyoma , erythropoietin , myoma , uterine leiomyoma , hysterectomy , medicine , pathogenesis , thrombopoietin , uterus , pathology , andrology , endocrinology , biology , stem cell , haematopoiesis , genetics
We report a patient with uterine myoma (leiomyoma) and erythrocytosis in whom erythropoietin (Epo) production in the leiomyoma tissue was identified by reverse transcription polymerase chain reaction (RT‐PCR) and enzyme‐linked immunosorbent assay (ELISA). A 48‐year‐old Japanese woman with uterine myoma showed marked erythrocytosis (haemoglobin: 20·2 g/dl, haematocrit: 61·1%, red blood cells: 6·51 × 10 12 /1). After hysterectomy, erythrocytosis rapidly disappeared. In the leiomyoma tissue collected from the patient, Epo mRNA expression was confirmed using RT‐PCR. Furthermore, ELISA showed that the Epo protein level was significantly increased compared with those in control tissues. It is suggested that the pathogenesis of erythrocytosis in patients with uterine myoma involves ectopic Epo production by leiomyoma tissues.