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Recombinant human factor VIIa in the management of amyloid‐associated factor X deficiency
Author(s) -
Boggio Lisa,
Green David
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02667.x
Subject(s) - recombinant factor viia , medicine , amyloidosis , factor viia , splenectomy , complication , clotting factor , factor x , recombinant dna , coagulation , gastroenterology , surgery , immunology , thrombin , platelet , tissue factor , spleen , chemistry , biochemistry , gene
Factor X deficiency is an important complication of amyloidosis. It is associated with severe bleeding that is difficult to control with plasma or prothrombin complex concentrates. Splenectomy ameliorates the factor X deficiency, but achieving satisfactory haemostasis for this operation is problematic. We report that a new clotting concentrate, recombinant factor VIIa, readily controls bleeding and makes splenectomy feasible.