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The retinoblastoma family member, p107, is active in non‐dividing monocyte‐derived dendritic cells
Author(s) -
Ardeshna K. M.,
Ahmed F.,
Devereux S.,
Thomas N. S. B.
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02640.x
Subject(s) - retinoblastoma , e2f , microbiology and biotechnology , transcription factor , cell cycle , retinoblastoma protein , monocyte , biology , cancer research , immunology , cell , gene , genetics
A member of the retinoblastoma family of cell cycle regulatory proteins, p107, is not normally expressed in non‐cycling cells. We demonstrate here that p107 is expressed in monocytes as they differentiate into dendritic cells under the influence of granulocyte‐macrophage colony‐stimulating factor and interleukin 4, a process shown not to involve cellular proliferation. We show that p107 is localized to the nucleus of these cells and is active, in that it binds an E2F‐DNA binding site, together with E2F transcription factors. These findings suggest a hitherto unknown role for p107 in non‐proliferating dendritic cells that warrants further investigation.