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Continuous complete remission in adult patients with acute lymphocytic leukaemia at a median observation of 12 years after autologous bone marrow transplantation
Author(s) -
Abdallah Alhossain,
Egerer Gerlinde,
Goldschmidt Hartmut,
Wannenmacher Michael,
Körbling Martin,
Ho Anthony D.
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02634.x
Subject(s) - medicine , bone marrow transplantation , bone marrow , acute lymphocytic leukemia , transplantation , complete remission , hematology , surgery , leukemia , oncology , chemotherapy , lymphoblastic leukemia
We report our long‐term experience with autologous bone marrow transplantation (ABMT) for 32 adult patients with acute lymphocytic leukaemia (ALL) in second or later remission (CR), or in first CR but with high‐risk. Bone marrow was purged with mafosfamide ( n = 25) or with immunomagnetic beads and monoclonal antibodies ( n = 7). Retrospective analysis showed that 12 out of 32 patients were in continuous complete remission (CCR) at a median of 143 months (range 66–181 months). A plateau was reached at 50 months and the disease‐free and overall survival rates were both 37·5%. It was notable that durable CCR could be achieved for patients in second (three out of nine) or third (one out of six) CR. ABMT could produce durable CCR and the long‐term outcome compared favourably with those reported for allogeneic transplantation.