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A dose of 75 μg/kg/d of i.v. anti‐D increases the platelet count more rapidly and for a longer period of time than 50 μg/kg/d in adults with immune thrombocytopenic purpura
Author(s) -
Newman Gregg C.,
Novoa Maria V.,
Fodero Erin M.,
Lesser Martin L.,
Woloski B. M. R.,
Bussel James B.
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02627.x
Subject(s) - medicine , platelet , adverse effect , thrombocytopenic purpura , premedication , prednisone , gastroenterology , acetaminophen , anesthesia
Treatment with 75 μg/kg/d intravenous (i.v.) anti‐D was compared with 50 μg/kg/d in a prospective randomized study of 27 RhD‐positive, human immunodeficiency virus‐negative, adult, acute, non‐splenectomized patients with immune thrombocytopenic purpura (ITP) and platelet counts ≤ 30 × 10 9 /l. The higher dose resulted in greater median d 1 (43 × 10 9 /l vs. 7·5 × 10 9 /l; P = 0·012) and d 7 (153 × 10 9 /l vs. 64·5 × 10 9 /l; P = 0·001) platelet increases despite no greater haemoglobin decrease. Children with acute ITP receiving 75 μg/kg/d had overnight platelet increases in seven out of nine cases. The duration of effect at the 75 μg/kg/d dose was 46 d vs. 21 d ( P = 0·03). Adverse events were mild to moderate and ameliorated with prednisone and acetaminophen premedication.