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Three cases of typical aplastic anaemia associated with a Philadelphia chromosome
Author(s) -
Suzan F.,
Terré C.,
Garcia I.,
Bastie J. N.,
Baumelou E.,
Gluckman E.,
Castaigne S.
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02594.x
Subject(s) - chromosomal translocation , medicine , chronic myeloid leukaemia , aplastic anemia , philadelphia chromosome , cytogenetics , immunology , pediatrics , chromosome , gastroenterology , oncology , bone marrow , biology , genetics , gene
We report three cases of typical aplastic anaemia (AA) associated with a Philadelphia chromosome. This translocation was detected at the time of diagnosis of AA (one patient) and when overt leukaemia was diagnosed (two patients: one chronic myeloid leukaemia and one acute lymphoblastic leukaemia) after AA therapy and recovery of blood counts. We discuss the literature arguments about considering some cases of AA as preleukaemic disorders and suggest that our cases illustrate the association of AA with a clonal malignant disorder. We conclude that cytogenetic analysis is necessary at diagnosis of AA or after recovery of blood counts.