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Somatostatin receptor scintigraphy useful in stage I–II Hodgkin's disease: more extended disease identified
Author(s) -
Lugtenburg P. J.,
Krenning E. P.,
Valkema R.,
Oei H. Y.,
Lamberts S. W. J.,
Eijkemans M. J. C.,
Van Putten W. L. J.,
Löwenberg B.
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02583.x
Subject(s) - medicine , scintigraphy , radiology , stage (stratigraphy) , nuclear medicine , somatostatin receptor , diaphragm (acoustics) , lesion , somatostatin , pathology , paleontology , physics , acoustics , loudspeaker , biology
Somatostatin receptor (SS‐R) scintigraphy successfully shows primary cancers and metastases in patients with a variety of SS‐R‐positive tumours. In vitro studies have shown that SS‐Rs are present in lymph nodes from patients with Hodgkin's disease (HD). We performed a prospective study in 126 newly diagnosed patients with HD and compared the results of SS‐R scintigraphy with conventional staging procedures, i.e. physical examination, computerized tomography (CT) scanning and other imaging techniques. We report positive scintigraphy in all patients. The lesion‐related sensitivity was 94% and varied from 98% for supradiaphragmatic lesions to 67% for infradiaphragmatic lesions. In comparison with CT scanning and ultrasonography, SS‐R scintigraphy provided superior results for the detection of Hodgkin's localizations above the diaphragm. In the intra‐abdominal region, the CT scan was more sensitive than the SS‐R scan. A false‐positive scan was rarely seen. In stages I and II supradiaphragmatic HD patients, SS‐R scintigraphy detected more advanced disease in 18% (15 out of 83) of patients, resulting in an upstaging to stage III or IV, thus directly influencing patient management. Our data would support the validity of SS‐R scanning as a powerful imaging technique for the staging of patients with HD.