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Cytotoxic T‐lymphocyte antigen‐4 microsatellite polymorphism is associated with multiple myeloma
Author(s) -
Zheng Chengyun,
Huang DeRen,
Liu Li,
Björkholm Magnus,
Holm Göran,
Yi Qing,
Sundblad Anne
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02552.x
Subject(s) - monoclonal gammopathy of undetermined significance , cytotoxic t cell , genotype , multiple myeloma , immunology , antigen , allele , biology , locus (genetics) , lymphocyte , monoclonal , monoclonal antibody , antibody , genetics , gene , in vitro
Multiple myeloma (MM) is a B‐lineage malignancy with unknown aetiology. It has been considered that predisposing genetic factors might be implicated in the disease. In this study, the microsatellite polymorphism in the exon 3 of the cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) gene was analysed in patients with MM and monoclonal gammopathy of undetermined significance (MGUS), together with ethnically matched healthy controls. The results showed that frequencies of the genotype 86/86 and of the allele 86 were significantly decreased in MM and MGUS compared with matched healthy controls, indicating that the CTLA‐4 microsatellite polymorphism might represent a susceptibility locus for MM and MGUS.