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High levels of reticulated platelets and thrombopoietin characterize fetal thrombopoiesis
Author(s) -
JilmaStohlawetz P.,
Homoncik M.,
Jilma B.,
Folman C. C.,
Von Dem Borne A. E. G. KR.,
Bernaschek G.,
Deutinger J.,
Ulm B.,
Eppel W.,
Panzer S.
Publication year - 2001
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2001.02524.x
Subject(s) - thrombopoiesis , thrombopoietin , platelet , fetus , medicine , platelet membrane glycoprotein , andrology , endocrinology , biology , pregnancy , megakaryocyte , microbiology and biotechnology , progenitor cell , haematopoiesis , stem cell , genetics
To characterize fetal thrombopoiesis, we determined plasma thrombopoietin (TPO) and glycocalicin levels, platelet counts and reticulated platelets (RP) of fetuses and compared them with the respective values of their mothers. Percutaneous umbilical vein sampling in abnormal pregnancies revealed twofold higher thrombopoietin levels and 20‐fold higher reticulated platelet counts, but lower levels of glycocalicin in fetuses compared with their mothers ( P < 0·05). Neither the expression of platelet glycoprotein Ib and IIb on platelets nor the platelet counts were different between mothers and their fetuses. These data indicate enhanced thrombopoiesis and/or increased platelet turnover in fetuses.