Premium
Two‐step immunoablative treatment with autologous peripheral blood CD34 + cell transplantation in an 8‐year‐old boy with autoimmune haemolytic anaemia
Author(s) -
Paillard C.,
Kanold J.,
Halle P.,
Yakouben K.,
Boiret N.,
Rapatel C.,
Berger M.,
Malpuech G.,
Deméocq F.
Publication year - 2000
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2000.02281.x
Subject(s) - haemolysis , medicine , transplantation , autoimmune disease , peripheral blood , chemotherapy , complete remission , immunology , surgery , disease
Life‐threatening haemolysis in children with autoimmune haemolytic anaemia (AIHA) occurs rarely. Many cases of severe autoimmune disease are currently treated with immunosuppressive high‐dose chemotherapy and autograft. We report here a case of a child with severe AIHA who did not respond to conventional treatments, but was cured with an autologous peripheral blood CD34 + cell transplantation. After d 16 post autograft, no further red cell transfusions were required. At 20 months post autograft, haematological complete remission persists.