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Fibrinogen polymorphisms are not associated with the risk of myocardial infarction
Author(s) -
Doggen C. J. M.,
Bertina R. M.,
Cats V. Manger,
Rosendaal F. R.
Publication year - 2000
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2000.02266.x
Subject(s) - fibrinogen , myocardial infarction , medicine , allele , cardiology , gene , genetics , biology
In the Study of Myocardial Infarctions Leiden , we investigated the prevalence of three polymorphisms in the α‐ and β‐fibrinogen genes among 560 patients with a myocardial infarction and 646 control subjects. Secondly, we studied the relationships between these polymorphisms and fibrinogen activity and antigen levels. The Taq I, Hae III and Bcl I polymorphisms in the fibrinogen gene were not associated with myocardial infarction. As we found an association of the rare B2 allele with fibrinogen levels and a similar, but weak, effect for the rare H2 allele, we conclude that a genetic propensity to high fibrinogen levels does not affect the risk of myocardial infarction. This is evidence against a causal role for fibrinogen levels in the aetiology of myocardial infarction.