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t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: characterization of a new subset of T acute lymphoblastic leukaemia
Author(s) -
Mecucci Cristina,
La Starza Roberta,
Negrini Massimo,
Sabbioni Silvia,
Crescenzi Barbara,
Leoni Pietro,
Di Raimondo Francesco,
Krampera Mauro,
Cimino Giuseppe,
Tafuri Agostino,
Cuneo Antonio,
Vitale Antonella,
Foà Robin
Publication year - 2000
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2000.02106.x
Subject(s) - chromosomal translocation , gene , fusion gene , abnormality , chromosomal abnormality , biology , medicine , cancer research , immunology , karyotype , genetics , chromosome , psychiatry
Two cases of T acute lymphoblastic leukaemia (T‐ALL) with an identical t(4;11)(q21;p15) translocation were identified within a prospective study on the biological and clinical features of adult ALL patients enrolled into the therapeutic protocol ALL0496 of the GIMEMA Italian Group. In both cases, the molecular characterization showed an involvement of the NUP98 gene on 11p15 which rearranges with the RAP1GDS1 gene on 4q21. The morphological and immunological features of the leukaemic cells, as well as the clinical behaviour and response to induction therapy, were the same in both patients. Based on the available data, the t(4;11)(q21;p15) translocation involving the NUP98–RAP1GDS1 fusion gene emerges as a new highly specific genetic abnormality that characterizes a subset of T‐ALL.