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Lack of BCL10 mutations in Hodgkin's disease‐derived cell lines
Author(s) -
Re Daniel,
Benenson Elena,
Wolf Jürgen,
Diehl Volker,
StaratschekJox Andrea
Publication year - 2000
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2000.02052.x
Subject(s) - bcl10 , reed–sternberg cell , biology , gene , cancer research , lymphoma , coding region , genetics , immunology , hodgkin lymphoma
The pathogenetic events leading to the malignant transformation of Hodgkin–Reed–Sternberg cells are unknown. As Hodgkin–Reed–Sternberg cells are resistant to CD95‐mediated apoptosis and chromosomal aberrations involving the 1p22 region harbouring the proapoptotic BCL10 gene represent a recurrent event in Hodgkin's disease‐derived cell lines, analysis of the BCL10 gene and its transcripts was performed. As transcription of wild‐type BCL10 was detected in all Hodgkin's disease‐derived cell lines analysed, alterations of the coding sequence of the BCL10 gene are unlikely to contribute to the malignant transformation of the Hodgkin–Reed–Sternberg cell.