Premium
Prevalence of factor V Leiden and prothrombin G20210A mutations in unselected patients with venous thromboembolism
Author(s) -
De Moerloose P.,
Reber G.,
Perrier A.,
Perneger T.,
Bounameaux H.
Publication year - 2000
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2000.02039.x
Subject(s) - medicine , factor v leiden , odds ratio , pulmonary embolism , gastroenterology , confidence interval , prothrombin g20210a , factor v , risk factor , thrombosis , deep vein , venous thrombosis , surgery
We determined the prevalence of factor V Leiden and of prothrombin G20210A mutations in a cohort of unselected outpatients ( n = 748) referred for suspected deep vein thrombosis (DVT) and/or pulmonary embolism (PE) and a pooled analysis of similar studies was also performed. Based on the clinical presentation, the prevalence of factor V Leiden was 15·7% in the 83 patients with DVT and 14·1% in the 99 patients with PE compared with 5·3% in patients without DVT and/or PE (control group). The prevalence of the prothrombin G20210A mutation did not differ among the three groups (3·9% for controls, 4·8% for DVT and 3·9% for PE patients). We then divided the 99 patients with PE by separately analysing those with PE but without DVT ( n = 57) and those with PE and DVT ( n = 42). Compared with the control group, the prevalence of factor V Leiden was 10·5%, odds ratio (OR) 2·10 [95% confidence interval (95% CI) 0·68–5·45] in patients with primary PE and 19·1%, OR 4·20 (95% CI 1·54–10·30) in patients with DVT and PE. For the prothrombin G20210A mutation, no statistically significant differences were found between the control group and the three other groups. In conclusion, our data and the pooled analysis indicate that patients with primary PE are less often affected by the factor V Leiden mutation. No statistically significant differences were observed between patients and controls for the prothrombin G20210A mutation.