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Prevention of worsening of severe thrombocytopenia after red cell transfusions by the use of leucocyte‐depleted blood
Author(s) -
Anna Schuh,
Wale Atoyebi,
Timothy Littlewood,
Chris Hatton,
Michael Bradburn,
Michael Murphy
Publication year - 2000
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2000.01840.x
Subject(s) - red cell , platelet , medicine , red blood cell , red blood cell transfusion , blood cell , platelet transfusion , gastroenterology , immunology , hematology , cell , blood transfusion , chemistry , biochemistry
Platelet counts were measured before and after red cell transfusions in 30 patients with anaemia and severe thrombocytopenia resulting from haematological diseases. There was a mean reduction of 1.1 × 10 9 /l ( P = 0.43) in the platelet count after transfusions of 2–3 units of leucocyte‐depleted red cell concentrates (20 patients). However, there was a mean reduction of 2.7 × 10 9 /l ( P = 0.03), ≈ 10%, in the platelet count after transfusions of non‐leucocyte‐depleted red cell concentrates (10 patients). The findings suggest that the forthcoming introduction of universal leucocyte depletion of red cell concentrates will minimize the worsening of thrombocytopenia that occurs in severely thrombocytopenic patients receiving standard non‐leucocyte‐depleted red cell concentrates.