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T‐prolymphocytic leukaemia with spontaneous remission
Author(s) -
Tsutomu Shichishima,
M Kawaguchi,
Takashi Machii,
Reiko Matsuoka,
Kaoru Ogawa,
Yukio Maruyama
Publication year - 2000
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2000.01836.x
Subject(s) - organomegaly , prolymphocytic leukemia , medicine , abnormality , gene rearrangement , complete remission , spontaneous remission , gastroenterology , karyotype , pathology , chemotherapy , leukemia , gene , chromosome , biology , disease , genetics , alternative medicine , chronic lymphocytic leukemia , psychiatry
T‐prolymphocytic leukaemia (T‐PLL) is a rare dis‐order with a poor prognosis. A 69‐year‐old man was diagnosed as having a small‐cell variant of T‐PLL according to the French–American–British classification by haematological, immunological and ultrastructural studies, although the cells had a CD7 − phenotype and no chromosomal abnormality. He had no symptoms or organomegaly. The number of his lymphocytes, 53.7 × 10 9 /l at the time of diagnosis, gradually decreased without therapy, and he was in complete remission 39 months later. A rearranged band in the T‐cell antigen receptor‐β gene, which was detected at the time of diagnosis, decreased or disappeared. This is the first report of a T‐PLL case with spontaneous complete remission.