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Transmission of symptomatic parvovirus B19 infection by fibrin sealant used during surgery
Author(s) -
Hino Masayuki,
Ishiko Osamu,
Honda Kenichi,
Yamane Takahisa,
Ohta Kensuke,
Takubo Takayuki,
Tatsumi Noriyuki
Publication year - 2000
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2000.01818.x
Subject(s) - parvovirus , fibrin , sealant , medicine , parvoviridae , virus , transmission (telecommunications) , virology , surgery , immunology , chemistry , organic chemistry , electrical engineering , engineering
Human parvovirus B19 infection has been shown to be transmissible by blood and blood products and to result in transient aplastic crisis in patients with rapid red cell turnover. We report three cases of iatrogenic parvovirus B19 infection resulting from the use of the same batch of fibrin sealant under operation. Fibrin sealant, which is a typical haemostatic agent produced from blood, has been used during surgery. Human parvovirus is resistant to existing virus‐inactivating techniques, suggesting that infection may occur from blood products contaminated with it. Use of recombinant products for these proteins may thus be necessary.