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Simultaneous occurrence of follicular lymphoma in two monozygotic twins
Author(s) -
Marco Fernando,
Manjón Raquel,
Richard Carlos,
Mazorra Francisco,
GarcíaValtuille Ana,
Delgado M. Dolores,
Loyo M. Luisa,
Cuadrado M. Angeles,
Zubizarreta Alberto
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01785.x
Subject(s) - vincristine , medicine , prednisone , cyclophosphamide , etoposide , follicular lymphoma , gastroenterology , lymphoma , melphalan , lymphoblastic lymphoma , chop , chemotherapy , surgery , immunology , t cell , immune system
Numerous cases of familial aggregation of Hodgkin's disease (HD) or non-Hodgkin's lymphoma (NHL) have been reported. An increased risk of HD in monozygotic twins of HD patients, compared to dizygotic twins has been demonstrated (Mack et al, 1995), providing strong evidence of a genetic susceptibility underlying HD. Among close relatives of patients with NHL, some authors have found that NHL was more frequent than expected by chance (Pottern et al, 1991), whereas others failed to prove this (Haim et al, 1982). NHL in monozygotic twins is a very rare ®nding which is associated to T phenotype (Schneider et al, 1995). In June 1995 a 48-year-old male was diagnosed with follicular lymphoma (small cleaved cell), stage IIA, having British Journal of Haematology, 1999, 107, 461±465