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Clinical significance of urinary albumin excretion in patients with non‐Hodgkin's lymphoma
Author(s) -
Pedersen Lars Møller,
Sørensen Peter Grundtvig
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01772.x
Subject(s) - microalbuminuria , medicine , microgram , lymphoma , lactate dehydrogenase , gastroenterology , urinary system , clinical significance , urine , albumin , excretion , non hodgkin's lymphoma , stage (stratigraphy) , disease , enzyme , biology , paleontology , biochemistry , in vitro
Slightly increased urinary albumin excretion rates (UAE) have been reported in patients with various types of human cancer. We measured UAE in 24 h urine samples from 48 untreated patients with non‐Hodgkin's lymphoma at diagnosis. In patients with a pretreatment UAE 20 μg/min, post‐treatment value of UAE was determined following completion of the last treatment. The median UAE was 15.0 μg/min and the prevalence of microalbuminuria (UAE 20 μg/min) was 39.6%. Increased UAE was significantly associated with Ann Arbor stage, performance status, serum lactate dehydrogenase (LDH) level, and the International Prognostic Index (IPI). The median posttreatment value of UAE was significantly lower than the pretreatment value ( P < 0.0001). Our data suggest a clinical and prognostic significance of UAE in patients with non‐Hodgkin's lymphoma.