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NG2 expression in MLL rearranged acute myeloid leukaemia is restricted to monoblastic cases
Author(s) -
Laurent Mauvieux,
Éric Delabesse,
Priscille Bourquelot,
Isabelle Radford–Weiss,
Anelyse Bennaceur,
Georges Flandrin,
Françoise Valensi,
Elizabeth Macintyre
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01730.x
Subject(s) - myeloid leukaemia , myeloid , medicine , population , biology , cancer research , immunology , environmental health
Expression of NG2 has been reported in the majority of paediatric acute leukaemia (AL) cases with MLL rearrangement. We demonstrated 7.1 positivity in 2/3 paediatric and 4/11 adult MLL rearranged acute myeloid leukaemia (AML) but in 0/28 adult AML without MLL rearrangement, thus extending the 100% specificity to adult cases. Positivity correlated with stage of maturation arrest since it was found in 0/6 immature AML but in 6/8 monoblastic cases. These data demonstrate that, if NG2 expression in AL is the (in)direct result of MLL rearrangement, such activation is restricted to a monoblastic population in AML. They also have practical implications for NG2 diagnostic screening strategies.