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Tumour necrosis factor polymorphisms and susceptibility to follicular lymphoma
Author(s) -
Fitzgibbon Jude,
Grenzelias Demetrios,
Matthews Janet,
Lister T. Andrew,
Gupta Rajnish K.
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01704.x
Subject(s) - follicular lymphoma , haplotype , allele , chromosomal translocation , locus (genetics) , major histocompatibility complex , biology , lymphoma , tumor necrosis factor alpha , medicine , immunology , genetics , gene , antigen
Follicular lymphoma is characterized in 85% of patients by the presence of a t(14;18) chromosomal translocation that results in overproduction of BCL2. In this study the distribution of high and low expressing TNF alleles at the TNF (−308) and LTα (+252) polymorphic sites in 121 patients with follicular lymphoma and 88 control individuals has been analysed. A reduction in high expressing haplotypes in patients compared to normal controls was found ( P = 0.055), with no significant difference observed in response rate or overall survival between patients with high or low expressing haplotypes. These results suggest that the TNF locus, or an adjacent locus within the MHC region, is an important genetic risk factor in this disease.