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Revision of the diagnosis of T‐zone lymphoma in the father of a patient with autoimmune lymphoproliferative syndrome type II
Author(s) -
Bosch Jutte van der Werff ten,
Delabie Jan,
Böhler Thomas,
Verschuere Johan,
Thielemans Kris
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01643.x
Subject(s) - medicine , lymphoma , pathological , autoimmune lymphoproliferative syndrome , differential diagnosis , lymphoproliferative disease , disease , lymphoproliferative disorders , lymph node , pathology , rare disease , autoimmune disease , lymph , pediatrics , apoptosis , biochemistry , chemistry , fas receptor , programmed cell death
Autoimmune lymphoproliferative syndrome (ALPS) is a disease of childhood characterized by typical clinical and laboratory findings. Here we describe an adult patient presenting with lymph node enlargement and splenomegaly. Pathological examination of an adenopathy supported the diagnosis of malignant T‐zone lymphoma. The patient was treated accordingly. 3 years later his child was diagnosed with ALPS. Therefore the diagnosis of the father's disease was reconsidered. Review of the slides and functional tests led to the diagnosis of ALPS in both father and son. ALPS should be considered as a possible differential diagnosis in adult patients presenting with rare types of T‐cell lymphomas.