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Age‐related changes in thrombopoietin in children: reference interval for serum thrombopoietin levels
Author(s) -
Ishiguro Akira,
Nakahata Tatsutoshi,
Matsubara Kousaku,
Hayashi Yasuhide,
Kato Takashi,
Suzuki Yoko,
Shimbo Toshikazu
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01641.x
Subject(s) - thrombopoietin , medicine , endocrinology , platelet , reference values , biology , haematopoiesis , genetics , stem cell
We studied thrombopoietin (TPO, Mpl ligand) values using a sensitive ELISA in 254 serum samples obtained from disease‐free children and adult volunteers. TPO was detected in all samples, and its values ranged widely from 0.25 to 9.18 fmol/ml. When analysed by dividing the subjects into 11 age groups, the mean TPO levels from birth to 1 month of age were increased (3.73–5.92 fmol/ml). The highest values were found 2 d after birth; TPO levels then gradually decreased to adult levels (0.83 fmol/ml). The relationship between TPO values and platelet counts was not significant in all subjects ( r = 0.27) or in children alone ( r = 0.12). In children > 1 month of age a 95% reference interval for serum TPO values was determined from 0.58 to 3.27 fmol/ml. A significant correlation was found between TPO values in serum and plasma; serum TPO values = −0.257 + 4.039 × plasma TPO values ( r = 0.951, P < 0.001, n = 22). This study is the first to report age‐dependent changes in blood TPO levels throughout child development. Serum TPO values were significantly high up to 1 month of age and were correlated with plasma TPO levels.