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P53 deletion is not a frequent event in multiple myeloma
Author(s) -
AvetLoiseau Hervé,
Li JianYong,
Godon Catherine,
Morineau Nadine,
Daviet Axelle,
Harousseau JeanLuc,
Facon Thierry,
Bataille Régis
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01615.x
Subject(s) - multiple myeloma , fluorescence in situ hybridization , in situ hybridization , bone marrow , incidence (geometry) , biology , locus (genetics) , cancer research , oncology , pathology , medicine , immunology , genetics , gene , gene expression , physics , optics , chromosome
Recently a high incidence of interstitial deletion of the P53 locus has been reported in multiple myeloma (MM) patients. Considering the importance of such an event, we analysed 79 patients with advanced‐stage disease using fluorescence in situ hybridization (FISH). Strikingly, we found only 7/79 patients with a P53 deletion. In order to rule out any differences in probe selection, we reanalysed all the patients with the same probe as that used in a previous study, and confirmed the low incidence of P53 deletion (7/79, 9%). The only explanation is a difference in hybridization efficiency. Since hybridization is far less efficient on malignant plasma cells than on other bone marrow cells we suggest that this poor hybridization efficiency may lead to a false P53 deletion.