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Haemopoietic reconstitution after sublethal irradiation: comparison of the effects of different haemopoietic cytokines on murine lymphocytes and bone marrow cells
Author(s) -
Frasca Daniela,
Guidi Francesco,
Barattini Paola,
Doria Gino
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01558.x
Subject(s) - bone marrow , haematopoiesis , immunology , hematology , biology , cancer research , medicine , stem cell , microbiology and biotechnology
Sublethally irradiated mice were injected with recombinant cytokines to stimulate haemopoietic reconstitution. Interleukin (IL)‐11 and IL‐6 were able to significantly accelerate the recovery of thymus, spleen and bone marrow cells when used in combination with IL‐3, but not alone. Stem cell factor (SCF) also displayed detectable effects when used with IL‐3. Conversely, the IL‐6 superagonist K‐7/D‐6 was able, even when used alone, to induce recovery of thymus, spleen and bone marrow cells up to the level of unirradiated controls. Together, these results indicate that it is possible to attain complete recovery of lymphoid organs and tissues as early as 7 d after irradiation by use of haemopoietic cytokines.