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Selective effect of cyclosporine monotherapy for pure red cell aplasia not associated with granular lymphocyte‐proliferative disorders
Author(s) -
Yamada Osamu,
Motoji Toshiko,
Mizoguchi Hideaki
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01552.x
Subject(s) - pure red cell aplasia , aplasia , lymphocyte , medicine , immunology , cell , red cell , bone marrow aplasia , biology , bone marrow , genetics
Morphological characteristics of lymphocytes and the response to cyclosporine treatment have revealed some unique patients with pure red cell aplasia. Lymphocytes from these patients consisted mainly of non‐granulated lymphocytes. All of the patients were successfully managed by cyclosporine monotherapy irrespective of prior treatment. A reduction in lymphocyte mass was not a prerequisite for the remission of pure red cell aplasia, and responses occurred within 1 month from the start of therapy. Clonal T‐cell proliferation was detected in four patients, which raised the possibility of idiopathic pure red cell aplasia being associated with a clonal proliferation of T cells. An examination of the lymphocytes in patients with pure red cell aplasia could potentially be used to plan better therapeutic modalities and assess prognosis.