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Enhanced adherence of β‐thalassaemic erythrocytes to endothelial cells
Author(s) -
Tavor Hovav,
Ada Goldfarb,
G.M. Artmann,
Saul Yedgar,
Gregory Barshtein
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01489.x
Subject(s) - hemoglobinopathy , thalassemia , medicine , red blood cell , hematological disorders , malaria , hemolytic anemia , immunology
The adherence of red blood cells (RBC) to endothelial cells (EC), shown to correlate with microvascular occlusion in sickle cell disease and malaria, is considered a major contributor to microcirculatory disorders. In the present study the adherence to EC was markedly enhanced with RBC from β‐thalassaemia major (TM) patients, and even more so with RBC from β‐thalassaemia intermedia (TI) patients (10‐fold and 25‐fold higher than normal, respectively). It is proposed that enhanced RBC/EC adherence may contribute to the microcirculatory disorders observed in thalassaemia, especially in TI patients who are particularly known to suffer from leg ulcers.