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Neurolymphomatosis in Waldenström's macroglobulinaemia
Author(s) -
Abad Sébastien,
Zagdanski AnneMarie,
Brechignac Sabine,
Thioliere Brigitte,
Brouet JeanClaude,
Mariette Xavier
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01482.x
Subject(s) - lymphoplasmacytic lymphoma , medicine , waldenstrom macroglobulinemia , infiltration (hvac) , leptomeninges , pathology , complication , nerve root , cerebrospinal fluid , bone marrow , magnetic resonance imaging , lumbar puncture , radiology , central nervous system , lymphoma , physics , thermodynamics
We report four patients with Waldenström's macroglobulinaemia with an unusual neurologic complication, neurolymphomatosis, characterized by meningeal and root nerve infiltration by lymphoplasmacytic cells. Patients presented with rapidly progressive leg proximal weakness. Examination of cerebrospinal fluid disclosed lymphoplasmacytic cells. Magnetic resonance imaging of the lumbar spine was suggestive of a tissular infiltration of leptomeninges and nerve roots. Chemotherapy and irradiation of involved tissues led to a remarkable and sustained neurological improvement.