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Chronic lymphocytic leukaemia and neuroendocrine cancer
Author(s) -
Russo F.,
Guadagni S.,
Corazzelli G.,
Frigeri F.,
Monda V. M.,
Abate G.
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01472.x
Subject(s) - trisomy , chronic lymphocytic leukemia , medicine , chromosome abnormality , cancer , pathology , neuroendocrine tumors , chromosome , oncology , cancer research , gastroenterology , biology , karyotype , leukemia , genetics , gene
We report a unique association between neuroendocrine cancer and chronic lymphocytic leukaemia (CLL) in a 63‐year‐old man. Neuroendocrine cancer was resistant to various conventional treatments and following loco‐regional progression we treated the patient with hypoxic pelvic perfusion of cisplatin 100 mg/m 2 plus mitomycin 40 mg/m 2 , using the stopflow method, for three cycles: a dramatic and surprising reduction of > 75% in the evaluable lesions was observed. The cumulative effect of treatment produced a complete response from CLL. At cytogenetic examination the neuroendocrine cells were diploid, whereas CLL cells showed trisomy 12. Moreover, deletion of the short arm of chromosome 3 was found in both neoplastic populations. Whether the abnormality seen on chromosome 3 in the two diseases represents a critical event is not known.